Concepedia

Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines

Jung-Hun Lee, Il Hwan Kim, Hana Yu, Jaeyoon Chung, Chang-Hyun Oh, Kyung Ho Yoo, Taebo Sim, Jung-Mi Hah

Bioorganic & Medicinal Chemistry Letters · 2010 · 33 citations · 13 references

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13

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

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Cancer Statistics, 2008

Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians · 2008 · 10.2K citations · Full text

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

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Rational design of inhibitors that bind to inactive kinase conformations

Yi Liu, Nathanael S. Gray · Nature Chemical Biology · 2006 · 1.1K citations · Full text

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Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis

Tim Eisen, T. Ahmad, Keith T. Flaherty et al. · British Journal of Cancer · 2006 · 636 citations · Full text

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