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Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry

Jun-ichi Kasuga, Minoru Ishikawa, Mitsuhiro Yonehara, Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi

Bioorganic & Medicinal Chemistry · 2010 · 27 citations · 27 references

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References

27

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

Peter Tontonoz, Erding Hu, Bruce M. Spiegelman · Cell · 1994 · 3.5K citations

, , +12

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Isabelle Issemann, Stephen Green · Nature · 1990 · 3.5K citations

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

Barry M. Forman, Jasmine Chen, Ronald M. Evans · Proceedings of the National Academy of Sciences · 1997 · 2.1K citations

, , +17

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Steven A. Kliewer, Barry M. Forman, Bruce Blumberg et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

, , +15

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

H. Keller, C Dreyer, Jeffrey A. Medin et al. · Proceedings of the National Academy of Sciences · 1993 · 949 citations

, , +17