Jun-ichi Kasuga

Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures

Takuji Oyama, Kenji Toyota, Tsuyoshi Waku et al. · Acta Crystallographica Section D Biological Crystallography · 2009 · 68 citations · Full text

Design, synthesis, and evaluation of a novel series of α-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) α/δ dual agonists for the treatment of metabolic syndrome

Jun-ichi Kasuga, Daisuke Yamasaki, Yoko Araya et al. · Bioorganic & Medicinal Chemistry · 2006 · 41 citations

Metabolic Syndrome, Novel Series, Biochemistry +11

Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) δ-selective agonists

Jun-ichi Kasuga, Izumi Nakagome, Atsushi Aoyama et al. · Bioorganic & Medicinal Chemistry · 2007 · 41 citations · Full text

δ-Selective Agonists, Biochemistry, Medicine +6

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Masahiko Kainuma, Jun-ichi Kasuga, Shinnosuke Hosoda et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 41 citations · Full text

Chemical Biology, Combinatorial Chemistry, Biochemistry +8

Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor α/δ dual agonists

Jun-ichi Kasuga, Makoto Makishima, Yuichi Hashimoto et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 38 citations · Full text

Biochemistry, Medicine, Pharmacological Agent +3