Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

Abstract

Our data suggest that tau enhances α-syn aggregation and toxicity and disrupts α-syn inclusion formation. This pathological synergistic effect between tau and α-syn may amplify the deleterious process and spread the damage in neurodegenerative diseases that show co-occurrence of both pathologies.