Tau Toxicity is a pathological mechanism in neurodegenerative disorders characterized by the aberrant aggregation and hyperphosphorylation of tau protein, leading to neuronal dysfunction and degeneration through disruption of microtubule stability, impaired axonal transport, and propagation of misfolded tau species.
639
Publications
56.6K
Citations
3.9K
Authors
955
Institutions
Publications per year
2017–2026
322
Parents
Publications
639
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Lars M. Ittner, Yazi D. Ke, Fabien Delerue et al. · Cell · 2010 · 1.8K citations · Full text
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Yang Shi, Kaoru Yamada, Shane A. Liddelow et al. · Nature · 2017 · 1.2K citations · Full text
Tauopathy in <i>Drosophila</i> : Neurodegeneration Without Neurofibrillary Tangles
Curtis W. Wittmann, Matthew Wszolek, Joshua M. Shulman et al. · Science · 2001 · 943 citations
Rapamycin alleviates toxicity of different aggregate-prone proteins
Zdenek Berger, Brinda Ravikumar, Fiona M. Menzies et al. · Human Molecular Genetics · 2005 · 659 citations · Full text
1–5 of 639
Authors
3.9K
- RKRakez Kayed
The University of Texas Medical Branch at Galveston, United States
30 publications · 3.3K citations
27
h-index
- USUrmi Sengupta
The University of Texas Medical Branch at Galveston, United States
18 publications · 2.4K citations
18
h-index
- EMEckhard Mandelkow�
Max Planck Unit for Structural Molecular Biology, Germany
17 publications · 2K citations
16
h-index
- EMEva‐Maria Mandelkow
Max Planck Unit for Structural Molecular Biology, Germany
19 publications · 2.3K citations
16
h-index
- JÁ
15
h-index
1–5 of 3.9K
Institutions
955
The University of Texas Medical Branch at Galveston
Galveston, United States
31 h-index
173 publications
20K citations
Harvard University
Cambridge, United States
26 h-index
152 publications
29.1K citations
German Center for Neurodegenerative Diseases
Bonn, Germany
25 h-index
120 publications
9.2K citations
Center of Advanced European Studies and Research
Bonn, Germany
18 h-index
52 publications
4.4K citations
Massachusetts General Hospital
Boston, United States
16 h-index
83 publications
13K citations
Inserm
Paris, France
16 h-index
91 publications
9.6K citations
Centro de Biología Molecular Severo Ochoa
Madrid, Spain
15 h-index
58 publications
6.1K citations
Universidad Autónoma de Madrid
Madrid, Spain
15 h-index
64 publications
6.6K citations
1–8 of 955
Venues
- Journal of Neuroscience
22 publications · 3.8K citations
20
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- Journal of Alzheimer s Disease
JAD · 25 publications · 1.2K citations
19
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- Human Molecular Genetics
22 publications · 2.4K citations
19
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- PLoS ONE
18 publications · 902 citations
17
h-index
- Journal of Biological Chemistry
JBC · 18 publications · 2.2K citations
17
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