Concepedia

Tau Fibrillization

Tau Fibrillization is the pathological self-assembly process in which soluble tau proteins undergo conformational changes and aggregate into insoluble, ordered fibrillar structures known as paired helical filaments, a hallmark of tauopathy in neurodegenerative diseases.

190

Publications

25.1K

Citations

899

Authors

297

Institutions

Publications per year

2017–2026

70

Variants

Tau Fibrillation

Parents

Publications

190

Neurodegenerative Tauopathies

Virginia M.‐Y. Lee, Michel Goedert, John Q. Trojanowski · Annual Review of Neuroscience · 2001 · 2.4K citations

, , +16

Cryo-EM structures of tau filaments from Alzheimer’s disease

Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He et al. · Nature · 2017 · 2.1K citations

, , +16

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

Bess Frost, Rachel Lauren Jacks, Marc I. Diamond · Journal of Biological Chemistry · 2009 · 1.3K citations · Full text

, , +17

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

Michel Goedert, Ross Jakes, M. G. Spillantini et al. · Nature · 1996 · 1K citations

, , +15

Structure-based classification of tauopathies

Yang Shi, Wenjuan Zhang, Yang Yang et al. · Nature · 2021 · 919 citations · Full text

, , +14

1–5 of 190

Authors

899

  1. MG
    Michel Goedert

    MRC Laboratory of Molecular Biology, United Kingdom

    17 publications · 9.5K citations

    17

    h-index

  2. VM
    Virginia M.‐Y. Lee

    University of Pennsylvania, United States

    16 publications · 5.1K citations

    16

    h-index

  3. JK
    Jeff Kuret

    The Ohio State University, United States

    14 publications · 1.2K citations

    13

    h-index

  4. JQ
    John Q. Trojanowski

    University of Pennsylvania, United States

    13 publications · 4.7K citations

    13

    h-index

  5. JÁ
    Jesús Ávila

    Centro de Biología Molecular Severo Ochoa, Spain

    11 publications · 642 citations

    11

    h-index

1–5 of 899

Institutions

297

  1. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    18 h-index

    89 publications

    54.2K citations

  2. University of Pennsylvania

    Philadelphia, United States

    16 h-index

    75 publications

    16.1K citations

  3. The Ohio State University

    Columbus, United States

    13 h-index

    42 publications

    3.4K citations

  4. Universidad Autónoma de Madrid

    Madrid, Spain

    11 h-index

    40 publications

    2.1K citations

  5. Centro de Biología Molecular Severo Ochoa

    Madrid, Spain

    11 h-index

    38 publications

    2.1K citations

  6. Institute on Aging

    San Francisco, United States

    10 h-index

    56 publications

    11.6K citations

  7. Tokyo Metropolitan Institute of Medical Science

    Tokyo, Japan

    10 h-index

    24 publications

    4.4K citations

  8. Medical Research Council

    London, United Kingdom

    8 h-index

    27 publications

    9.6K citations

1–8 of 297

Venues

  1. Journal of Biological Chemistry

    JBC · 15 publications · 3.5K citations

    15

    h-index

  2. Biochemistry

    12 publications · 1.1K citations

    12

    h-index

  3. FEBS Letters

    10 publications · 1.1K citations

    10

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 9 publications · 632 citations

    9

    h-index

  5. Acta Neuropathologica

    7 publications · 663 citations

    7

    h-index

1–5