Concepedia

Pyrazolopyrimidines as dual Akt/p70S6K inhibitors

Kenneth D. Rice, Moon H. Kim, Joerg Bussenius, Neel K. Anand, Charles M. Blazey, O.J. Bowles, Lynne Canne-Bannen, Diva S.-M. Chan, Baili Chen, Erick W. Co,

Bioorganic & Medicinal Chemistry Letters · 2012 · 28 citations · 6 references

DOIFull text

Open access

Concepts

References

6

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Kathryn O’Reilly, F. Rojo, Qing‐Bai She et al. · Cancer Research · 2006 · 2.6K citations · Full text

, , +16

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

Tim Cloughesy, Koji Yoshimoto, Phioanh L. Nghiemphu et al. · PLoS Medicine · 2008 · 591 citations · Full text

, , +14

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

Violeta Serra, Maurizio Scaltriti, Ludmila Prudkin et al. · Oncogene · 2011 · 534 citations · Full text

, , +17

Guidelines for Reporting Health Research: The EQUATOR Network's Survey of Guideline Authors

Iveta Simera, Douglas G. Altman, David Moher et al. · PLoS Medicine · 2008 · 216 citations · Full text

, , +14

Structure-Based Optimization of Novel Azepane Derivatives as PKB Inhibitors

C.B. Breitenlechner, Thomas Wegge, L. Berillon et al. · Journal of Medicinal Chemistry · 2004 · 101 citations · Full text

, , +17