Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

Kenneth D. Rice, Naing Aay, Neel K. Anand, +20

ACS Medicinal Chemistry Letters

Drug TargetErk/map Kinase CascadeStructural InsightPharmacotherapyChemical Biology +19

Asymmetric Synthesis of γ-Hydroxy α,β-Unsaturated Aldehydes via Enantioselective Direct Addition of Propargyl Acetate to Aldehydes

Emad El‐Sayed, Neel K. Anand, Erick M. Carreira

Organic Letters

Propargyl AcetateEnantioselective SynthesisEngineeringAsymmetric SynthesisOrganic Chemistry +8

Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90

Joerg Bussenius, Charles M. Blazey, Naing Aay, +34

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyProtein FunctionMedicineNatural SciencesMolecular Biology +5

Palladium(0)-Catalysed Arylations using Pyrrole and Indole 2-Boronic Acids

Christopher N. Johnson, Geoffrey Stemp, Neel K. Anand, +2

Synlett

Cross-coupling ReactionEngineeringSuzuki CouplingPyrrole-2-boronic AcidOrganic Chemistry +7

Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Craig S. Takeuchi, Byung Gyu Kim, Charles M. Blazey, +25

Journal of Medicinal Chemistry

Compound 28Drug TargetPharmacotherapyChemical BiologyPharmaceutical Chemistry +18

NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential

Takahiro Miyazaki, Irene Choi, Werner Rubas, +15

Journal of Pharmacology and Experimental Therapeutics

Pyrazolopyrimidines as dual Akt/p70S6K inhibitors

Kenneth D. Rice, Moon H. Kim, Joerg Bussenius, +28

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicineRational Drug DesignDual Akt/p70s6k Inhibitors +5

RETRACTED: Biomimetic approach to Galbulimina type I alkaloids

Kirill Tchabanenko, Richard Chesworth, Jeremy S. Parker, +4

Tetrahedron

PharmacologyGalbulimina TypeSecondary MetaboliteNatural Product Synthesis

Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors

Joerg Bussenius, Neel K. Anand, Charles M. Blazey, +28

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineNatural Sciences +9

Abstract 3755: Comprehensive antitumor immune activation by a novel TLR7/8 targeting agent NKTR-262 combined with CD122-biased immunostimulatory cytokine NKTR-214

Saul Kivimäe, Marlene Hennessy, Rhoneil Pena, +14

Cancer Research

ImmunologyImmunoeditingPathologyAbstract 3755Immunologic Mechanism +22