Naing Aay

Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

Kenneth D. Rice, Naing Aay, Neel K. Anand et al. · ACS Medicinal Chemistry Letters · 2012 · 161 citations · Full text

Drug Target, Erk/map Kinase Cascade, Structural Insight +21

Discovery of XL413, a potent and selective CDC7 inhibitor

Elena S. Koltun, Amy Lew Tsuhako, David S. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 90 citations · Full text

Medicinal Chemistry, Drug Target, Selective Cdc7 Inhibitor +5

Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90

Joerg Bussenius, Charles M. Blazey, Naing Aay et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 77 citations · Full text

Molecular Pharmacology, Protein Function, Medicine +7

Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Craig S. Takeuchi, Byung Gyu Kim, Charles M. Blazey et al. · Journal of Medicinal Chemistry · 2013 · 65 citations · Full text

Compound 28, Drug Target, Pharmacotherapy +20

The design, synthesis, and biological evaluation of PIM kinase inhibitors

Amy Lew Tsuhako, David S. Brown, Elena S. Koltun et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 37 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +10