Charles M. Blazey

Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

Kenneth D. Rice, Naing Aay, Neel K. Anand et al. · ACS Medicinal Chemistry Letters · 2012 · 161 citations · Full text

Drug Target, Erk/map Kinase Cascade, Structural Insight +21

Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90

Joerg Bussenius, Charles M. Blazey, Naing Aay et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 77 citations · Full text

Molecular Pharmacology, Protein Function, Medicine +7

Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Craig S. Takeuchi, Byung Gyu Kim, Charles M. Blazey et al. · Journal of Medicinal Chemistry · 2013 · 65 citations · Full text

Compound 28, Drug Target, Pharmacotherapy +20

Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast

Bruno Tse, James M. Balkovec, Charles M. Blazey et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 29 citations

Alkyl Side-chain Derivatives, Antifungal Agent, Biochemistry +5

Pyrazolopyrimidines as dual Akt/p70S6K inhibitors

Kenneth D. Rice, Moon H. Kim, Joerg Bussenius et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 27 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +7