Concepedia

The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

Elisa Greggio, Jean‐Marc Taymans, Yuejun Zhen, John Ryder, Renée Vancraenenbroeck, Alexandra Beilina, Peng Sun, Junpeng Deng, Howard Jaffe, Veerle Baekelandt,

Biochemical and Biophysical Research Communications · 2009 · 150 citations · 24 references

DOI

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24

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith et al. · Nature · 2007 · 3.1K citations · Full text

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Elisa Greggio, Shushant Jain, Ann E. Kingsbury et al. · Neurobiology of Disease · 2006 · 748 citations · Full text

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith, Zhong Pei, Haibing Jiang et al. · Nature Neuroscience · 2006 · 623 citations

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Andrew B. West, Darren J. Moore, Catherine Choi et al. · Human Molecular Genetics · 2007 · 606 citations

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Mahaboobi Jaleel, R. Jeremy Nichols, Mária Deák et al. · Biochemical Journal · 2007 · 515 citations · Full text

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