R. Jeremy Nichols

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Mahaboobi Jaleel, R. Jeremy Nichols, Mária Deák et al. · Biochemical Journal · 2007 · 515 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice et al. · Biochemical Journal · 2010 · 404 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +13

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

Nicolas Dzamko, Mária Deák, Fayçal Hentati et al. · Biochemical Journal · 2010 · 388 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

The Vaccinia-related Kinases Phosphorylate the N′ Terminus of BAF, Regulating Its Interaction with DNA and Its Retention in the Nucleus

R. Jeremy Nichols, Matthew S. Wiebe, Paula Traktman · Molecular Biology of the Cell · 2006 · 262 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

R. Jeremy Nichols, Nicolas Dzamko, Jessica E. Hutti et al. · Biochemical Journal · 2009 · 203 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17