Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB

Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

Steven A. Rosenberg, Paul Aebersold, Kenneth Cornetta et al. · New England Journal of Medicine · 1990 · 1.3K citations · Full text

Medicine, Immunology, Oncology +16

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

Stanley R. Riddell, Käthe S. Watanabe, J. M. Goodrich et al. · Science · 1992 · 1.2K citations

Life Sciences, Immunology, Infectious Diseases +17

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

Cliona M. Rooney, Colton A. Smith, Catherine Y. Ng et al. · Blood · 1998 · 1.1K citations

Life Sciences, Immunology, Oncology +15

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

Ignacio Melero, Walter W. Shuford, S A Newby et al. · Nature Medicine · 1997 · 891 citations

Life Sciences, Immunology, Oncology +14

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

Helen E. Heslop, Catherine Y. Ng, Congfen Li et al. · Nature Medicine · 1996 · 833 citations

Life Sciences, Immunology, Infectious Diseases +13