Concepedia

Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in mice

Makiko Fukaya, Yoshiaki Tamura, Yuko Chiba, Toshihiro Tanioka, Ji Mao, Yoko Inoue, Marina Yamada, Christian Waeber, Yukari Ido-Kitamura, Tadahiro Kitamura,

Biochemical and Biophysical Research Communications · 2013 · 29 citations · 34 references

DOI

Concepts

References

34

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

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The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Javier R. Revollo, Andrew A. Grimm, Shin‐ichiro Imai · Journal of Biological Chemistry · 2004 · 993 citations · Full text

, , +15

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Laura Bordone, Maria Carla Motta, Frédéric Picard et al. · PLoS Biology · 2005 · 708 citations · Full text

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Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

Kathryn A. Moynihan, Andrew A. Grimm, Marie M. Plueger et al. · Cell Metabolism · 2005 · 628 citations · Full text

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