Concepedia

Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

Kathryn A. Moynihan, Andrew A. Grimm, Marie M. Plueger, Ernesto Bernal‐Mizrachi, Eric L. Ford, Corentin Cras‐Méneur, M. Alan Permutt, Shin‐ichiro Imai

Cell Metabolism · 2005 · 628 citations · 41 references

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41

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Konrad T. Howitz, Kevin J. Bitterman, Haim Cohen et al. · Nature · 2003 · 3.8K citations

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Joseph T. Rodgers, Carles Lerín, Wilhelm Haas et al. · Nature · 2005 · 3.1K citations

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Matt Kaeberlein, Mitch McVey, Leonard Guarente · Genes & Development · 1999 · 2.3K citations · Full text

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Frédéric Picard, Martin V. Kurtev, Acharawan Topark‐Ngarm et al. · Nature · 2004 · 1.9K citations · Full text

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