Concepedia

Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer

Qing Dong, Douglas R. Dougan, Xianchang Gong, Petro Halkowycz, Bohan Jin, Toufike Kanouni, Shawn M. O’Connell, Nicholas Scorah, Lihong Shi, Michael B. Wallace,

Bioorganic & Medicinal Chemistry Letters · 2011 · 122 citations · 19 references

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19

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

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ras oncogenes in human cancer: a review.

Joyce Bos · PubMed · 1989 · 5.1K citations

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The MAPK signaling cascade

Rony Seger, Edwin G. Krebs · The FASEB Journal · 1995 · 3.4K citations

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

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<sup>V600E</sup> BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway

Christine A. Pratilas, Barry S. Taylor, Qing Ye et al. · Proceedings of the National Academy of Sciences · 2009 · 614 citations · Full text

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