Concepedia

Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents

Anh P. Truong, Gary D. Probst, Jose Aquino, Larry Y. Fang, Louis Brogley, Jennifer M. Sealy, Roy K. Hom, John Tucker, Varghese John, Jay S. Tung,

Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · 40 references

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40

Global prevalence of dementia: a Delphi consensus study

Cleusa P. Ferri, Martin Prince, Carol Brayne et al. · The Lancet · 2005 · 5.3K citations · Full text

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

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Neurodegenerative Tauopathies

Virginia M.‐Y. Lee, Michel Goedert, John Q. Trojanowski · Annual Review of Neuroscience · 2001 · 2.4K citations

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Jürgen Götz, F. Chen, Jo Van Dorpe et al. · Science · 2001 · 1.5K citations

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1.1K citations

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