Permeability Modulation is a bioisosteric strategy that systematically alters the membrane permeability of a pharmacologically active compound by substituting bioisosteres to optimize molecular properties influencing passive diffusion, thereby distinguishing it from other bioisosteric replacements aimed primarily at metabolic stability or target affinity.
69
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3.2K
Citations
355
Authors
111
Institutions
Publications per year
2017–2026
15
Parents
Publications
69
1–5 of 69
Authors
355
- BG
2
h-index
- YO
2
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- JS
2
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- GR
2
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- GM
2
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1–5 of 355
Institutions
111
Charles University
Prague, Czechia
2 h-index
11 publications
250 citations
The University of Tokyo
Tokyo, Japan
2 h-index
4 publications
149 citations
The University of Texas Southwestern Medical Center
Dallas, United States
2 h-index
3 publications
44 citations
Centre National de la Recherche Scientifique
Paris, France
2 h-index
6 publications
75 citations
Merck & Co., Inc., Rahway, NJ, USA (United States)
Rahway, United States
2 h-index
5 publications
136 citations
Universidade Nova de Lisboa
Lisbon, Portugal
2 h-index
4 publications
279 citations
AstraZeneca (United Kingdom)
Cambridge, United Kingdom
2 h-index
19 publications
347 citations
Rede de Química e Tecnologia
Porto, Portugal
2 h-index
5 publications
309 citations
1–8 of 111
Venues
- Macromolecules
3 publications · 175 citations
3
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- Journal of Medicinal Chemistry
3 publications · 176 citations
3
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- Antimicrobial Agents and Chemotherapy
AAC · 3 publications · 353 citations
3
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- Bioorganic & Medicinal Chemistry Letters
3 publications · 50 citations
3
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- American Journal of Physiology-Heart and Circulatory Physiology
2 publications · 38 citations
2
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1–5