Concepedia

Permeability Enhancement

Permeability Enhancement is a prodrug design strategy in which the parent drug’s molecular structure is transiently modified (typically via reversible promoieties) to increase its ability to traverse biological barriers such as epithelial or endothelial membranes, thereby improving its absorption and bioavailability.

1.7K

Publications

95.7K

Citations

7.1K

Authors

1.7K

Institutions

Publications per year

2017–2026

376

Parents

Children

Publications

1.7K

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

R. L. Juliano, Victor Ling · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1976 · 3.3K citations

, , +11

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Uma Prabhakar, Hiroshi Maeda, Eva M. Sevick‐Muraca et al. · Cancer Research · 2013 · 1.5K citations

, , +17

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

Daniel T. Connolly, Deborah M. Heuvelman, R Nelson et al. · Journal of Clinical Investigation · 1989 · 1.3K citations · Full text

, , +14

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

W. Gregory Roberts, George E. Palade · Journal of Cell Science · 1995 · 1K citations

, , +16

Enhanced Permeability and Retention (EPR) Effect for Anticancer Nanomedicine Drug Targeting

Khaled Greish · Methods in molecular biology · 2010 · 823 citations

, , +14

1–5 of 1.7K

Authors

7.1K

  1. AB
    Andreas Bernkop‐Schnürch

    Universität Innsbruck, Austria

    18 publications · 786 citations

    16

    h-index

  2. KV
    Kateřina Vávrová

    Charles University, Czechia

    16 publications · 504 citations

    14

    h-index

  3. WI
    William I. Higuchi

    University of Utah, United States

    13 publications · 497 citations

    13

    h-index

  4. AH
    Alexandr Hrabálek

    Charles University, Czechia

    13 publications · 381 citations

    12

    h-index

  5. LF
    Liang Fang

    Shenyang Pharmaceutical University, China

    13 publications · 402 citations

    12

    h-index

1–5 of 7.1K

Institutions

1.7K

  1. University of Utah

    Salt Lake City, United States

    19 h-index

    73 publications

    4K citations

  2. Shenyang Pharmaceutical University

    Shenyang, China

    19 h-index

    154 publications

    4.8K citations

  3. Charles University

    Prague, Czechia

    16 h-index

    98 publications

    3.6K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    43 publications

    3.7K citations

  5. Hebrew University of Jerusalem

    Jerusalem, Israel

    15 h-index

    53 publications

    4.1K citations

  6. University of California, San Francisco

    San Francisco, United States

    15 h-index

    37 publications

    2.2K citations

  7. Harvard University

    Cambridge, United States

    15 h-index

    67 publications

    18.5K citations

  8. University of Kansas

    Lawrence, United States

    14 h-index

    67 publications

    2.2K citations

1–8 of 1.7K

Venues

  1. International Journal of Pharmaceutics

    114 publications · 5.4K citations

    44

    h-index

  2. Journal of Controlled Release

    55 publications · 3.4K citations

    35

    h-index

  3. Journal of Pharmaceutical Sciences

    57 publications · 3.3K citations

    32

    h-index

  4. Pharmaceutical Research

    44 publications · 3K citations

    31

    h-index

  5. PubMed

    Repository · 78 publications · 3.7K citations

    28

    h-index

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