BACE1 is the major β-secretase for generation of Aβ peptides by neurons

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

Neurodegenerative Diseases, Protein Secretion, Molecular Neuroscience +8

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

Alzheimer's Disease, Biochemistry, Proteasome +3

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Hong Lin, Gerald Koelsch, Xinli Lin et al. · Science · 2000 · 701 citations

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

Jan Näslund, Angelika Schierhorn, Ulf Hellman et al. · Proceedings of the National Academy of Sciences · 1994 · 469 citations

Aging, Relative Abundance, Neurochemical Biomarkers +18