Concepedia

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy, Hongjin Wen, David Borchelt, Donald L. Price, Philip C. Wong

Nature Neuroscience · 2001 · 1.1K citations · 11 references

DOI

Concepts

References

11

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

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Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

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Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Hong Lin, Gerald Koelsch, Xinli Lin et al. · Science · 2000 · 706 citations

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Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

Jan Näslund, Angelika Schierhorn, Ulf Hellman et al. · Proceedings of the National Academy of Sciences · 1994 · 471 citations

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