Inhibition of Human Immunodeficiency Virus (HIV) Production by 5′-Hydrogenphosphonates of 3′-Azido-2′,3′- dideoxynucleosides

Abstract

Abstract 3′-Azido-2′.3′-dideoxynucleoside 5′-hydrogenphos-phonates with thymine, adenine, guanine and cytosine bases inhibit HIV-1 reproduction In MT4 cell cultures. The most active was 5′-hydrogenphosphonate of 3′-azldo-2′,3′-dideoxythymidlne. Equi-molar mixture of all four hydrogenphosphonates is shorn to be less toxic in comparison with each of compounds taken separately.