Piet Herdewijn

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels, Jan Balzarini, Masanori Baba et al. · Journal of Virological Methods · 1988 · 1.6K citations

Life Sciences, Infectious Diseases, Analytical Chemistry +12

Synthetic Genetic Polymers Capable of Heredity and Evolution

Vitor B. Pinheiro, Alexander I. Taylor, Christopher Cozens et al. · Science · 2012 · 713 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Jesper B. Bramsen, Maria Bach Laursen, A. Nielsen et al. · Nucleic Acids Research · 2009 · 353 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro

Masanori Baba, Rudi Pauwels, Piet Herdewijn et al. · Biochemical and Biophysical Research Communications · 1987 · 344 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +13

Differential Patterns of Intracellular Metabolism of 2′,3′-Didehydro-2′,3′-dideoxythymidine and 3′-Azido-2′,3′-dideoxythymidine, Two Potent Anti-human Immunodeficiency Virus Compounds

Jan Balzarini, Piet Herdewijn, Erik De Clercq · Journal of Biological Chemistry · 1989 · 340 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +8