CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

Angela M. Thornton, Ethan M. Shevach

The Journal of Experimental Medicine

T-regulatory CellImmunologyRegulatory T CellsCd4 T Cell ResponsesImmunotherapy +14

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Jason D. Fontenot, Jeffrey P. Rasmussen, Marc A. Gavin, +1

Nature Immunology

InflammationCytokineInterleukin 2Autoimmune DiseaseT-regulatory Cell +9

CD4+CD25+ Immunoregulatory T Cells

Rebecca S. McHugh, Matthew J. Whitters, Ciriaco A. Piccirillo, +4

Immunity

Autoimmune DiseaseT-regulatory CellImmunologyAutoimmunityCd4 T Cell Responses +3

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, +10

Journal of Clinical Investigation

Inducing and expanding regulatory T cell populations by foreign antigen

Karsten Kretschmer, Irina Apostolou, Daniel Hawiger, +3

Nature Immunology

Autoimmune DiseaseAllergyLymphocyte DevelopmentT-regulatory CellPathogenesis +9

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

Qizhi Tang, Kammi Henriksen, Mingying Bi, +6

The Journal of Experimental Medicine

Anergic PhenotypeT-regulatory CellImmunologyRegulatory T CellsImmunotherapy +15

Homeostatic maintenance of natural <i>Foxp3</i> + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Ruka Setoguchi, Shohei Hori, Takeshi Takahashi, +1

The Journal of Experimental Medicine

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, +10

Journal of Clinical Investigation

NutritionT Cell HyporesponsivenessImmunologyGastrointestinal Peptide HormoneObesity +16

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

Elisabeth Suri‐Payer, Anna Z. Amar, Angela M. Thornton, +1

The Journal of Immunology

Lymphocyte DevelopmentT-regulatory CellImmunologyRegulatory T CellsCd4 T Cell Responses +15

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

Emmanuel Zorn, Erik A. Nelson, Mehrdad Mohseni, +9

Blood