Concepedia

T-cell Regulation

T-Cell Regulation is a biological mechanism within the adaptive immune system that modulates the activation, differentiation, and functional responses of T lymphocytes to maintain immune homeostasis and prevent excessive reactivity, particularly in the contexts of allergen tolerance and resistance to parasitic infection.

2.4K

Publications

230.7K

Citations

12.1K

Authors

2.2K

Institutions

Publications per year

2017–2026

318

Variants

T-cell Immunoregulation

Parents

Publications

2.4K

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Weihong Liu, Amy Putnam, Gregory L. Szot et al. · The Journal of Experimental Medicine · 2006 · 2.6K citations · Full text

, , +17

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Silvia Deaglio, Karen M. Dwyer, Wenda Gao et al. · The Journal of Experimental Medicine · 2007 · 2.4K citations · Full text

, , +15

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

Graham M. Lord, Giuseppe Matarese, Jane K. Howard et al. · Nature · 1998 · 2.2K citations

, , +14

A Cell Culture Model for T Lymphocyte Clonal Anergy

Ronald H. Schwartz · Science · 1990 · 1.9K citations

, , +17

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Jeong Kim, Jeffrey P. Rasmussen, Alexander Y. Rudensky · Nature Immunology · 2006 · 1.8K citations

, , +14

1–5 of 2.4K

Authors

12.1K

  1. SS
    Shimon Sakaguchi

    Kyoto University, Japan

    22 publications · 7.1K citations

    20

    h-index

  2. AY
    Alexander Y. Rudensky

    Howard Hughes Medical Institute, United States

    17 publications · 6.5K citations

    17

    h-index

  3. RK
    Richard K. Gershon

    Yale University, United States

    14 publications · 1.3K citations

    13

    h-index

  4. HC
    Harvey Cantor

    Dana-Farber Cancer Institute, United States

    14 publications · 2.8K citations

    13

    h-index

  5. RA
    Richard A. Flavell

    Yale University, United States

    11 publications · 3.3K citations

    11

    h-index

1–5 of 12.1K

Institutions

2.2K

  1. Harvard University

    Cambridge, United States

    60 h-index

    413 publications

    74.2K citations

  2. Inserm

    Paris, France

    49 h-index

    386 publications

    47.7K citations

  3. National Institutes of Health

    Bethesda, United States

    49 h-index

    315 publications

    55K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    47 h-index

    163 publications

    37.1K citations

  5. Brigham and Women's Hospital

    Boston, United States

    41 h-index

    190 publications

    42.5K citations

  6. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    40 h-index

    170 publications

    27.2K citations

  7. Memorial Sloan Kettering Cancer Center

    New York, United States

    36 h-index

    177 publications

    47.4K citations

  8. University of Pennsylvania

    Philadelphia, United States

    33 h-index

    198 publications

    33.5K citations

1–8 of 2.2K

Venues

  1. The Journal of Immunology

    JI · 406 publications · 33.6K citations

    102

    h-index

  2. The Journal of Experimental Medicine

    108 publications · 22.3K citations

    67

    h-index

  3. Immunity

    63 publications · 22K citations

    56

    h-index

  4. Blood

    85 publications · 11.3K citations

    50

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 74 publications · 8.1K citations

    50

    h-index

1–5