Concepedia
Cancer · 2001 · 179 citations · 16 references
The results are compatible with the notion that increased expression of Skp2 may have a causative role in decreasing the levels of p27 in aggressive colorectal carcinomas.
16
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
Michele Pagano, Sun W. Tam, Anne M. Theodoras et al. · Science · 1995 · 1.8K citations
Protein Function, Cell Regulation, Ubiquitin-proteasome Pathway +15
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Andrea C. Carrano, Esther Eytan, Avram Hershko et al. · Nature Cell Biology · 1999 · 1.5K citations
Ubiquitin-mediated Degradation, Signal Transduction, Cell Regulation +9
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
Massimo Loda, Barry Cukor, Sun W. Tam et al. · Nature Medicine · 1997 · 1K citations
Proteasome-dependent Degradation, Medicine, Colorectal Cancer +8
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
Peggy L. Porter, Kathleen E. Malone, Patrick J. Heagerty et al. · Nature Medicine · 1997 · 918 citations
Breast Oncology, Cell Regulation, Medicine +9
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
Charles Catzavelos, Nandita Bhattacharya, Yee Ung et al. · Nature Medicine · 1997 · 843 citations
Breast Oncology, Medicine, Primary Breast Cancer +6