Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas - Concepedia

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Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

179

Citations

16

References

2001

Year

Dan Hershko, Gil Bornstein, Ofer Ben‐Izhak, Andrea C. Carrano, Michele Pagano, Michael M. Krausz, Avram Hershko

Abstract

The results are compatible with the notion that increased expression of Skp2 may have a causative role in decreasing the levels of p27 in aggressive colorectal carcinomas.

References

	Year	Citations
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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 Andrea C. Carrano, Esther Eytan, Avram Hershko, Nature Cell Biology Ubiquitin-mediated DegradationSignal TransductionCell RegulationCdk Inhibitor P27Medicine	1999	1.5K
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas Massimo Loda, Barry Cukor, Sun W. Tam, Nature Medicine Proteasome-dependent DegradationMedicineColorectal CancerPathologyCancer Biology	1997	1K
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients Peggy L. Porter, Kathleen E. Malone, Patrick J. Heagerty, Nature Medicine Breast OncologyCell RegulationMedicineCancer BiologyBreast Cancer	1997	918
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p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27 Lyuben Tsvetkov, Kun‐Huei Yeh, Soo-Jung Lee, Current Biology	1999	786
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells Hedwig Sutterlüty, Eric Chatelain, Alain Marti, Nature Cell Biology Signal TransductionInduces S PhaseCell DivisionP27kip1 DegradationNatural Sciences	1999	697
pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase Hui Zhang, Ryûji Kobayashi, Konstantin Galaktionov, Cell Signal TransductionSignaling PathwayCell DivisionCell RegulationNatural Sciences	1995	459
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Vincenzo Esposito, Alfonso Baldi, Antonio De Luca, PubMed Tumor BiologyP27 Protein ExpressionPrognostic RoleP27 DegradationMedicine	1997	421
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. P. Tan, Blake Cady, Molly Wanner, PubMed Surgical OncologyBreast OncologyLow P27Cancer ManagementPathology	1997	354

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