Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase - Concepedia

Concepedia

Publication | Open Access

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

DOI Full Paper Access

256

Citations

16

References

2001

Year

Shinji Negoro, Keita Kunisada, Yasushi Fujio, Masanobu Funamoto, Martine I. Darville, Décio L. Eizirik, Tomoaki Osugi, Masahiro Izumi, Yuichi Oshima, Yoshikazu Nakaoka,

Abstract

The activation of STAT3 induces a protective effect on H/R-induced cardiomyocyte damage, mainly by inducting MnSOD. The STAT3-mediated signal is proposed as a therapeutical target of ROS-induced cardiomyocyte injury.

References

	Year	Citations

Page 1