Yoshikazu Nakaoka

Efficacy and safety of tocilizumab in patients with refractory Takayasu arteritis: results from a randomised, double-blind, placebo-controlled, phase 3 trial in Japan (the TAKT study)

Yoshikazu Nakaoka, Mitsuaki Isobe, Syuji Takei et al. · Annals of the Rheumatic Diseases · 2017 · 386 citations · Full text

Medicine, Internal Medicine, Pharmacotherapy +13

Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension

Takahiro Hashimoto-Kataoka, Naoki Hosen, Takashi Sonobe et al. · Proceedings of the National Academy of Sciences · 2015 · 257 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Shinji Negoro, Keita Kunisada, Yasushi Fujio et al. · Circulation · 2001 · 257 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Amelioration of sepsis by TIE2 activation–induced vascular protection

Sangyeul Han, Seung‐Jun Lee, Seung‐Jun Lee et al. · Science Translational Medicine · 2016 · 201 citations

Veterinary Medicine, Immunology, Pharmacology +15

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

Masanori Obana, Makiko Maeda, Koji Takeda et al. · Circulation · 2010 · 177 citations · Full text

Life Sciences, Cardiology, Molecular Biology +17