G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes

Mutsuo Harada, Yingjie Qin, Hiroyuki Takano, +17

Nature Medicine

Cardiac MuscleCardiomyopathyHeart FailureSignal TransductionG-csf Prevents +10

Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy

Keita Kunisada, Shinji Negoro, Eiroh Tone, +6

Proceedings of the National Academy of Sciences

Cardiac MuscleHeart FailureImmunologyCardiovascular ToxicityStructural Heart Disease +18

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Shinji Negoro, Keita Kunisada, Yasushi Fujio, +10

Circulation

Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes

Keita Kunisada, Eiroh Tone, Yasushi Fujio, +3

Circulation

Glycoprotein 130 Regulates Cardiac Myocyte Survival in Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation and Bcl-xL/Caspase-3 Interaction

Shinji Negoro, Hidemasa Oh, Eiroh Tone, +5

Circulation

Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes

Hidemasa Oh, Yasushi Fujio, Keita Kunisada, +4

Journal of Biological Chemistry

Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines

Quan Lin, Raymond Lai, Lucian R. Chirieac, +9

American Journal Of Pathology

Tumor BiologySignal TransductionSignaling PathwayCell RegulationConstitutive Activation +10

Activation of JAK-STAT and MAP Kinases by Leukemia Inhibitory Factor Through gp130 in Cardiac Myocytes

Keita Kunisada, Hisao Hirota, Yasushi Fujio, +4

Circulation

Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma

Hesham M. Amin, Timothy J. McDonnell, Yupo Ma, +9

Oncogene

Selective InhibitionLymphoid NeoplasiaHematological MalignancyMedicineCycle Arrest +10

Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes

Masanobu Funamoto, Yasushi Fujio, Keita Kunisada, +9

Journal of Biological Chemistry

Cardiac MuscleCardiovascular FunctionGp130 IncreaseCellular PhysiologyTranscriptional Regulation +19