The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou, +5

Cell

InflammationCytokineLymphocyte DevelopmentImmune RegulationImmunology +7

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov, Koji Atarashi, Nicolas Manel, +14

Cell

DysbiosisMucosal ImmunologyMicrobiologyGut BarrierMicrobiome +3

Transforming growth factor-β induces development of the TH17 lineage

Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn, +7

Nature

Developmental BiologyTh17 LineageCell ProliferationCell GrowthGene Expression +1

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Yan Zheng, Patricia Valdez, Dimitry M. Danilenko, +8

Nature Medicine

InflammationCytokineHost ResponseMicrobial PathogensMedicine +12

Phenotypic and functional features of human Th17 cells

Francesco Annunziato, Lorenzo Cosmi, Veronica Santarlasci, +13

The Journal of Experimental Medicine

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Liang Zhou, Jared E. Lopes, Mark M. W. Chong, +9

Nature

Transcriptional RegulationSignaling PathwayLymphocyte DevelopmentImmune Cell DevelopmentT-regulatory Cell +9

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

Eva V. Acosta Rodríguez, Laura Rivino, Jens Geginat, +5

Nature Immunology

Adaptive Immune SystemImmune Cell DevelopmentImmunologyImmunodominanceAntigenic Specificity +10

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Francisco J. Quintana, Alexandre S. Basso, Antonio Iglesias, +6

Nature

Signal TransductionMolecular PhysiologyMolecular RegulationTh17 Cell DifferentiationAryl Hydrocarbon Receptor +7

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Marc Veldhoen, Keiji Hirota, Astrid M. Westendorf, +4

Nature

InflammationAutoimmune DiseaseImmunotoxicologyAryl Hydrocarbon ReceptorImmune Regulation +6

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

Valérie Gaboriau‐Routhiau, Sabine Rakotobé, Emelyne Lécuyer, +11

Immunity

BiologyDysbiosisKey RoleMucosal ImmunologyMicrobiota +10