Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

Veterinary Medicine, Genetics, Pharmacology +13

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

Charles R. Yates, Eugene Y. Krynetski, Thrina Loennechen et al. · Annals of Internal Medicine · 1997 · 763 citations

Life Sciences, Genetics, Pharmacology +13

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

Lynne Lennard, J S Lilleyman, Jon Van Loon et al. · The Lancet · 1990 · 659 citations

Life Sciences, Genetics, Pediatrics +9

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

Jean‐Frédéric Colombel, Nicolas Ferrari, Hervé Debuysère et al. · Gastroenterology · 2000 · 615 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Preponderance of Thiopurine S-Methyltransferase Deficiency and Heterozygosity Among Patients Intolerant to Mercaptopurine or Azathioprine

William E. Evans, Yuen Yi Hon, Lisa Bomgaars et al. · Journal of Clinical Oncology · 2001 · 403 citations

Medicine, Hematology, Pharmacology +14