The design of potent hydrazones and disulfides as cathepsin S inhibitors

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

James T. Palmer, David Rasnick, Jeffrey L. Klaus et al. · Journal of Medicinal Chemistry · 1995 · 504 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, Altmetric Attention Score +17

Cathepsin S activity regulates antigen presentation and immunity.

Richard J. Riese, Richard Mitchell, Jóse A. Villadangos et al. · Journal of Clinical Investigation · 1998 · 313 citations · Full text

Immune Regulation, Immunology, Antigen Processing +16

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

Sebastián Amigorena, Paul Webster, James R. Drake et al. · The Journal of Experimental Medicine · 1995 · 145 citations · Full text

Proteinlipid Interaction, Immunology, Molecular Biology +20

Mixed-inhibitor-prodrug as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

Marie Claude Fournié-Zaluski, Pascale Coric, Serge Turcaud et al. · Journal of Medicinal Chemistry · 1992 · 140 citations

Pharmaceutical Science, Pharmacotherapy, Enkephalin-degrading Enzymes +18

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L

Dieter Brömme, Jeffrey L. Klaus, Kathleen Okamoto et al. · Biochemical Journal · 1996 · 139 citations · Full text