Concepedia

Hydrazone Linkers

Hydrazone Linker is a pH-sensitive covalent tether in prodrug design that belongs to the class of acid-labile linkers and is characterized by a hydrazone bond formed between a ketone or aldehyde group of a drug and a hydrazide moiety on a carrier, enabling selective drug release in acidic environments such as tumor tissues or endosomes.

448

Publications

22.8K

Citations

2.4K

Authors

720

Institutions

Publications per year

2017–2026

190

Parents

Publications

448

Crystalline Covalent Organic Frameworks with Hydrazone Linkages

Fernando J. Uribe‐Romo, Christian J. Doonan, Hiroyasu Furukawa et al. · Journal of the American Chemical Society · 2011 · 966 citations

, , +12

Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia

Philip R. Hamann, Lois M. Hinman, Irwin Hollander et al. · Bioconjugate Chemistry · 2001 · 587 citations

, , +17

Polyester Dendritic Systems for Drug Delivery Applications:  In Vitro and In Vivo Evaluation

Omayra L. Padilla De Jesús, Henrik Ihre, Lucie Gagné et al. · Bioconjugate Chemistry · 2002 · 503 citations

, , +17

Chemically Cross-Linked Cellulose Nanocrystal Aerogels with Shape Recovery and Superabsorbent Properties

Xuan Yang, Emily D. Cranston · Chemistry of Materials · 2014 · 468 citations

, , +15

Unprotected Peptides as Building Blocks for the Synthesis of Peptide Dendrimers with Oxime, Hydrazone, and Thiazolidine Linkages

Jun Shao, James P. Tam · Journal of the American Chemical Society · 1995 · 340 citations

, , +8

1–5 of 448

Authors

2.4K

  1. VJ
    Vygintas Jankauskas

    Vilnius University, Lithuania

    11 publications · 180 citations

    10

    h-index

  2. JV
    Juozas V. Gražulevičius

    Kaunas University of Technology, Lithuania

    8 publications · 146 citations

    8

    h-index

  3. VG
    Vytautas Getautis

    Kaunas University of Technology, Lithuania

    8 publications · 136 citations

    8

    h-index

  4. VG
    Valentas Gaidelis

    Vilnius University, Lithuania

    6 publications · 99 citations

    6

    h-index

  5. TM
    Tadas Malinauskas

    Kaunas University of Technology, Lithuania

    6 publications · 107 citations

    6

    h-index

1–5 of 2.4K

Institutions

720

  1. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    65 publications

    2.6K citations

  2. Kaunas University of Technology

    Kaunas, Lithuania

    12 h-index

    57 publications

    1.1K citations

  3. Vilnius University

    Vilnius, Lithuania

    11 h-index

    21 publications

    377 citations

  4. Chinese Academy of Sciences

    Beijing, China

    11 h-index

    50 publications

    3.6K citations

  5. Al-Azhar University

    Cairo, Egypt

    8 h-index

    19 publications

    899 citations

  6. Shenyang Pharmaceutical University

    Shenyang, China

    7 h-index

    50 publications

    1.2K citations

  7. National University of Singapore

    Singapore, Singapore

    6 h-index

    23 publications

    836 citations

  8. Cairo University

    Giza, Egypt

    6 h-index

    12 publications

    381 citations

1–8 of 720

Venues

  1. Journal of Molecular Structure

    28 publications · 784 citations

    18

    h-index

  2. European Journal of Medicinal Chemistry

    21 publications · 1.8K citations

    18

    h-index

  3. Bioorganic Chemistry

    17 publications · 720 citations

    17

    h-index

  4. Bioconjugate Chemistry

    15 publications · 1.8K citations

    15

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    16 publications · 1.1K citations

    15

    h-index

1–5