Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

Abstract

The ferrocene analogue <bold>4b</bold> had an IC₅₀ = 4 nM (HDAC1), 180 nM (HDAC8) and was effective in a <italic>Xenopus</italic> model of tubulin deacetylation. Analogue <bold>4a</bold> displayed mainly μM IC₅₀ values against HDACs apart from HDAC6 (IC₅₀ = 69 nM).