An in Vitro Mechanistic Study to Elucidate the Desipramine/Bupropion Clinical Drug-Drug Interaction

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 437 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants

L M Hesse, Karthik Venkatakrishnan, Michael H. Court et al. · Drug Metabolism and Disposition · 2000 · 399 citations

Medicine, Biochemistry, Pharmacology +17

Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

Stephanie Faucette, Roy L. Hawke, Edward L. LeCluyse et al. · Drug Metabolism and Disposition · 2000 · 356 citations

Medicine, Biochemistry, Pharmacology +17

‘In silico’ simulations to assess the ‘in vivo’ consequences of ‘in vitro’ metabolic drug–drug interactions

Amin Rostami‐Hodjegan, Geoff Tucker · Drug Discovery Today Technologies · 2004 · 239 citations

Medicine, Pharmacokinetics, Pharmacology +14

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

K. Br�sen, J G Hansen, Karin Kramer Nielsen et al. · European Journal of Clinical Pharmacology · 1993 · 193 citations

Medicine, Pharmacology, Pharmacotherapy +13