Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

H.K. Crewe, MS Lennard, GT Tucker et al. · British Journal of Clinical Pharmacology · 1992 · 471 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms

Søren H. Sindrup, Lars F. Gram, Kim Brøsen et al. · Pain · 1990 · 467 citations

Medicine, Pharmacology, Pharmacotherapy +17

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

K. Br�sen, L. F. Gram · European Journal of Clinical Pharmacology · 1989 · 285 citations

Medicine, Toxicology, Molecular Pathology +6

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

Masaaki Kagimoto, Markus H. Heim, Keiko Kagimoto et al. · Journal of Biological Chemistry · 1990 · 267 citations · Full text

Medicine, Genetics, Pharmacology +17

The relationship between paroxetine and the sparteine oxidation polymorphism

Søren H. Sindrup, Kim Brøsen, Lars F. Gram et al. · Clinical Pharmacology & Therapeutics · 1992 · 207 citations

Medicine, Pharmacokinetics, Pharmacology +14