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Discovery, optimisation and in vivo evaluation of novel GPR119 agonists

Katy J. Brocklehurst, Anders Broo, Roger J. Butlin, Hayley S. Brown, David S. Clarke, Öjvind Davidsson, Kristin Goldberg, Sam D. Groombridge, Elizabeth E. Kelly, Andrew G. Leach,

Bioorganic & Medicinal Chemistry Letters · 2011 · 15 citations · 22 references

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22

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

Hilary A. Overton, Adam J. Babbs, S. M. Doel et al. · Cell Metabolism · 2006 · 648 citations · Full text

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A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

Zhi‐Liang Chu, Christopher J. Carroll, Jean Alfonso et al. · Endocrinology · 2008 · 380 citations

, , +17

A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release

Zhi‐Liang Chu, Robert M. Jones, Hongmei He et al. · Endocrinology · 2007 · 292 citations

, , +17

Seven evolutionarily conserved human rhodopsin G protein‐coupled receptors lacking close relatives

Robert Fredriksson, Pär J. Höglund, David E. Gloriam et al. · FEBS Letters · 2003 · 289 citations

, , +15

Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT<sub>1D</sub> Receptor Ligands with Improved Pharmacokinetic Profiles

Monique B. van Niel, Ian Collins, Margaret S. Beer et al. · Journal of Medicinal Chemistry · 1999 · 157 citations · Full text

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