Sam D. Groombridge

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Scott Boyd, Joanna Brookfield, Susan E. Critchlow et al. · Journal of Medicinal Chemistry · 2015 · 92 citations · Full text

Drug Target, Selective Inhibitors, Chemical Biology +18

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

James S. Scott, Alan M. Birch, Katy J. Brocklehurst et al. · Journal of Medicinal Chemistry · 2012 · 74 citations · Full text

Glycobiology, Chemical Biology, Molecular Recognition +17

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88^L265P Diffuse Large B-Cell Lymphoma

James S. Scott, Sébastien L. Degorce, Rana Anjum et al. · Journal of Medicinal Chemistry · 2017 · 56 citations · Full text

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

Linda Sundström, Susanna Myhre, Monika Sundqvist et al. · PLoS ONE · 2017 · 51 citations · Full text

Gpr120 Null Mice, Insulin Signaling, Gastrointestinal Peptide Hormone +21

Rationally Designing Safer Anilines: The Challenging Case of 4-Aminobiphenyls

Alan M. Birch, Sam D. Groombridge, Robert V. Law et al. · Journal of Medicinal Chemistry · 2012 · 49 citations

Combinatorial Chemistry, Medicinal Chemistry, Designing Safer Anilines +12