Sam D. Groombridge

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Scott Boyd, Joanna Brookfield, Susan E. Critchlow et al. · Journal of Medicinal Chemistry · 2015 · 96 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

James S. Scott, Alan M. Birch, Katy J. Brocklehurst et al. · Journal of Medicinal Chemistry · 2012 · 75 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88^L265P Diffuse Large B-Cell Lymphoma

James S. Scott, Sébastien L. Degorce, Rana Anjum et al. · Journal of Medicinal Chemistry · 2017 · 56 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +10

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

Linda Sundström, Susanna Myhre, Monika Sundqvist et al. · PLoS ONE · 2017 · 55 citations · Full text

Life Sciences, Endocrinology, Pharmacology +17

Rationally Designing Safer Anilines: The Challenging Case of 4-Aminobiphenyls

Alan M. Birch, Sam D. Groombridge, Robert V. Law et al. · Journal of Medicinal Chemistry · 2012 · 49 citations

Pharmacy, Chemistry, Medicinal Chemistry +15