David S. Clarke

Pharmacokinetics of Vandetanib: Three Phase I Studies in Healthy Subjects

Paul Martín, Stuart Oliver, Sarah-Jane Kennedy et al. · Clinical Therapeutics · 2011 · 84 citations

Healthy Subjects, Pharmacological Study, Medicine +5

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

James S. Scott, Alan M. Birch, Katy J. Brocklehurst et al. · Journal of Medicinal Chemistry · 2012 · 74 citations · Full text

Glycobiology, Chemical Biology, Molecular Recognition +17

Synthesis and Activity of a Novel Series of 3-Biarylquinuclidine Squalene Synthase Inhibitors

George R. Brown, David S. Clarke, Alan J. Foubister et al. · Journal of Medicinal Chemistry · 1996 · 66 citations · Full text

Discovery and Optimization of a Series of Carbazole Ureas as NPY5 Antagonists for the Treatment of Obesity

M. Block, Scott Boyer, Wayne Brailsford et al. · Journal of Medicinal Chemistry · 2002 · 65 citations · Full text

Component Aniline, Medicinal Chemistry, Biochemistry +15

Sequential Double α-Arylation of <i>N</i>-Allylureas by Asymmetric Deprotonation and N→C Aryl Migration

Daniel J. Tetlow, Ulrich Hennecke, James Raftery et al. · Organic Letters · 2010 · 61 citations