David S. Clarke

Pharmacokinetics of Vandetanib: Three Phase I Studies in Healthy Subjects

Paul Martín, Stuart Oliver, Sarah-Jane Kennedy et al. · Clinical Therapeutics · 2011 · 84 citations

Pharmacy, Pharmacokinetics, Pharmacology +6

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

James S. Scott, Alan M. Birch, Katy J. Brocklehurst et al. · Journal of Medicinal Chemistry · 2012 · 75 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Optimization of a Series of Carbazole Ureas as NPY5 Antagonists for the Treatment of Obesity

Scott Boyer, Wayne Brailsford, David R. Brittain et al. · Journal of Medicinal Chemistry · 2002 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthesis and Activity of a Novel Series of 3-Biarylquinuclidine Squalene Synthase Inhibitors

George R. Brown, David S. Clarke, Alan J. Foubister et al. · Journal of Medicinal Chemistry · 1996 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Sequential Double α-Arylation of <i>N</i>-Allylureas by Asymmetric Deprotonation and N→C Aryl Migration

Daniel J. Tetlow, Ulrich Hennecke, James Raftery et al. · Organic Letters · 2010 · 61 citations

Natural Sciences, Chemistry, Catalysis +10