Hayley S. Brown

Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

Hayley S. Brown, Michael J. Griffin, J. Brian Houston · Drug Metabolism and Disposition · 2006 · 208 citations

Prediction of<i>in vivo</i>drug–drug interactions from<i>in vitro</i>data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

Hayley S. Brown, Kiyomi Ito, Aleksandra Galetin et al. · British Journal of Clinical Pharmacology · 2005 · 148 citations · Full text

Prediction of In Vivo Drug-Drug Interactions from In Vitro Data

Hayley S. Brown, Aleksandra Galetin, David Hallifax et al. · Clinical Pharmacokinetics · 2006 · 131 citations

Systems Pharmacology, Drug Interactions, Drug Target +12

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

James S. Scott, Alan M. Birch, Katy J. Brocklehurst et al. · Journal of Medicinal Chemistry · 2012 · 74 citations · Full text

Glycobiology, Chemical Biology, Molecular Recognition +17

Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for Ki Determination

Hayley S. Brown, Anthony Chadwick, J. Brian Houston · Drug Metabolism and Disposition · 2007 · 53 citations