Concepedia

Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy

Kim H.T. Paraiso, Inna V. Fedorenko, Liliana Cantini, Ana Cecelia Munko, MacLean Hall, Vernon K. Sondak, Jane L. Messina, Keith T. Flaherty, Keiran S.M. Smalley

British Journal of Cancer · 2010 · 309 citations · 25 references

DOIFull text

Open access

Abstract

Combined BRAF/MEK inhibition may be one strategy to prevent the emergence of drug resistance in BRAF-V600E-mutated melanomas.

References

25

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.6K citations · Full text

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

Charles M. Rudin, Christine L. Hann, John Laterra et al. · New England Journal of Medicine · 2009 · 1K citations · Full text

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<i>Smoothened</i> Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Robert L. Yauch, Gerrit J.P. Dijkgraaf, Bruno Alicke et al. · Science · 2009 · 837 citations · Full text

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MEK1 mutations confer resistance to MEK and B-RAF inhibition

Krishna G. Vijayendran, Marie Zipser, Allison M. Sawyer et al. · Proceedings of the National Academy of Sciences · 2009 · 628 citations · Full text