Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · British Journal of Clinical Pharmacology · 1999 · 745 citations · Full text

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Metabolomic Profiling, Pharmacotherapy, Cytochrome P-450pa +16

Genetic Polymorphism in the 5'-Flanking Region of HumanCYP1A2 Gene: Effect on the CYP1A2 Inducibility in Humans

Mitsutoshi Nakajima, Tsuyoshi Yokoi, Mayumi Mizutani et al. · The Journal of Biochemistry · 1999 · 345 citations

Molecular Pharmacology, 5'-Flanking Region, Genetics +14

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

W. Kalow, Bing-Kou Tang · Clinical Pharmacology & Therapeutics · 1991 · 264 citations

The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors.

Birgitte Rasmussen, Thomas Heiberg Brix, Kirsten Ohm Kyvik et al. · Pharmacogenetics · 2002 · 235 citations