Multispecific Organic Anion Transporter Is Responsible for the Biliary Excretion of the Camptothecin Derivative Irinotecan and its Metabolites in Rats

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

Medicinal Chemistry, Chemoprevention Strategy, Camptothecin Derivative Cpt-11 +12

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

E Gupta, Timothy M. Lestingi, Rosemarie Mick et al. · PubMed · 1994 · 506 citations

Metabolic Fate, Gastrointestinal Pharmacology, Gastroenterology +21

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Julianne Fassberg, Valentino J. Stella · Journal of Pharmaceutical Sciences · 1992 · 462 citations

Engineering, Biotransformation, Biochemistry +9

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Robert Hertzberg, Mary Jo Caranfa, Kenneth G. Holden et al. · Journal of Medicinal Chemistry · 1989 · 411 citations

Validation of a recording spectrophotometric method for measurement of membrane-associated Mg- and NaK-ATPase activity.

Bruce F. Scharschmidt, E B Keeffe, Nancy M. Blankenship et al. · PubMed · 1979 · 353 citations