Hideo Hakusui

Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.

T Satoh, Masakiyo Hosokawa, Ryo Atsumi et al. · Biological and Pharmaceutical Bulletin · 1994 · 173 citations · Full text

Multispecific Organic Anion Transporter Is Responsible for the Biliary Excretion of the Camptothecin Derivative Irinotecan and its Metabolites in Rats

Xiaoyan Chu, Yukio Kato, Kayoko Niinuma et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 163 citations · Full text

Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion

Ryo Atsumi, Wataru Suzuki, Hideo Hakusui · Xenobiotica · 1991 · 101 citations

Gastrointestinal Pharmacology, Secondary Metabolite, Biliary Excretion +20

Pharmacokinetics and tolerance of DU-6859a, a new fluoroquinolone, after single and multiple oral doses in healthy volunteers

M Nakashima, Toshihiko Uematsu, Kazuhiro Kosuge et al. · Antimicrobial Agents and Chemotherapy · 1995 · 77 citations · Full text

Mild Transient Diarrhea, Pharmacological Study, Drug Crystals +12

Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4′-hydroxylation phenotype and genotype*

Μakoto Tanaka, Tadashi Ohkubo, Koichi Otani et al. · Clinical Pharmacology & Therapeutics · 1997 · 73 citations