Adenosine Triphosphate-Competitive mTOR Inhibitors: A New Class of Immunosuppressive Agents That Inhibit Allograft Rejection

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Dos D. Sarbassov, Siraj M. Ali, Do‐Hyung Kim et al. · Current Biology · 2004 · 2.7K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta et al. · Molecular Cell · 2006 · 2.6K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +6

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt et al. · Nature Cell Biology · 2004 · 2.1K citations

Life Sciences, Cell Biology, Molecular Biology +14

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang et al. · Journal of Biological Chemistry · 2009 · 1.8K citations · Full text

Life Sciences, Oncology, Pharmacology +14

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Greg M. Delgoffe, Kristen Pollizzi, Adam T. Waickman et al. · Nature Immunology · 2011 · 1.1K citations · Full text

Life Sciences, Immunology, Molecular Biology +16