Nature Biotechnology · 2015 · 787 citations · 24 references
Life SciencesMolecular BiologyOncologyDrug DiscoveryGenome EditingMolecular OncologyCancer BiotechnologyCancer GenomicsCrispr-cas SystemsTarget Site SelectionTargeted Cancer TherapyVirtual ScreeningCrispr-cas9 Genome EditingCrispr-cas9 ValidationDrug Repurposing In CancerGenome-wide Crispr ScreeningProtein Binding DomainsProtein Dimerization DomainsProtein-protein Interaction Domains
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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text
Multiplex Genome Engineering Using CRISPR/Cas Systems
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Genome engineering using the CRISPR-Cas9 system
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RNA-Guided Human Genome Engineering via Cas9
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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science · 2013 · 5.5K citations · Full text