Christopher R. Vakoc

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

Medicine, Immunology, Therapeutic Efficacy +7

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang et al. · Nature · 2011 · 1.9K citations

Hematological Malignancy, Hematology, Myeloid Neoplasia +7

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

Isaia Barbieri, Konstantinos Tzelepis, Luca Pandolfini et al. · Nature · 2017 · 1.1K citations · Full text

Hematological Malignancy, Mixed-phenotype Acute Leukemia, Promoter-bound Mettl3 +5

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Hervé Tiriac, Pascal Belleau, Dannielle D. Engle et al. · Cancer Discovery · 2018 · 1.1K citations · Full text

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

Junwei Shi, Eric Wang, Joseph P. Milazzo et al. · Nature Biotechnology · 2015 · 754 citations · Full text

Cancer Drug Targets, Genome Surgery, Molecular Biology +9