Inverse Relationship of Protein Concentration and Aggregation

Conformation Changes of Proteins

Rufus Lumry, Henry Eyring · The Journal of Physical Chemistry · 1954 · 866 citations

Life Sciences, Biochemistry, Protein Biochemistry +7

The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation.

Jeffrey L. Cleland, Melissa Powell, S J Shire · PubMed · 1993 · 542 citations

Pharmacy, Biochemistry, Pharmaceutics +17

Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

Victoria Sluzky, J A Tamada, Alexander M. Klibanov et al. · Proceedings of the National Academy of Sciences · 1991 · 518 citations

Natural Sciences, Biochemistry, Chemistry +15

Protein denaturation by combined effect of shear and air-liquid interface

Yuh‐Fun Maa, Chung C. Hsu · Biotechnology and Bioengineering · 1997 · 349 citations · Full text

Natural Sciences, Biochemistry, Biophysics +15

Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

Narendra B. Bam, Jeffrey L. Cleland, Janet Yang et al. · Journal of Pharmaceutical Sciences · 1998 · 284 citations

Life Sciences, Endocrinology, Pharmacology +9