Concepedia

Protein Aggregation Modeling

Protein Aggregation Modeling is a computational or theoretical framework that specifically characterizes the mechanisms, dynamics, and structural evolution of protein assemblies into insoluble aggregates, distinguishing it from general protein folding or interaction modeling by focusing on pathogenic misfolding and aggregation pathways.

200

Publications

13.9K

Citations

689

Authors

322

Institutions

Publications per year

2017–2026

53

Parents

Publications

200

Rationalization of the effects of mutations on peptide andprotein aggregation rates

Fabrizio Chiti, Massimo Stefani, Niccolò Taddei et al. · Nature · 2003 · 1.1K citations

, , +12

Molecular mechanisms of protein aggregation from global fitting of kinetic models

Georg Meisl, Julius B. Kirkegaard, Paolo Arosio et al. · Nature Protocols · 2016 · 789 citations

, , +17

Design of therapeutic proteins with enhanced stability

Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser et al. · Proceedings of the National Academy of Sciences · 2009 · 597 citations · Full text

, , +17

Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases

Amol Pawar, Kateri F. DuBay, Jesús Zurdo et al. · Journal of Molecular Biology · 2005 · 585 citations

, , +17

A Nonlocal Continuum Model for Biological Aggregation

Chad M. Topaz, Andrea L. Bertozzi, Mark A. Lewis · Bulletin of Mathematical Biology · 2006 · 504 citations

, , +14

1–5 of 200

Authors

689

  1. SV
    Salvador Ventura

    Universitat Autònoma de Barcelona, Spain

    11 publications · 817 citations

    11

    h-index

  2. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    7 publications · 3.2K citations

    7

    h-index

  3. CJ
    Christopher J. Roberts

    University of Delaware, United States

    7 publications · 921 citations

    7

    h-index

  4. VI
    Valentín Iglesias

    Universitat Autònoma de Barcelona, Spain

    6 publications · 323 citations

    6

    h-index

  5. MV
    Michele Vendruscolo

    University of Cambridge, United Kingdom

    6 publications · 1.9K citations

    6

    h-index

1–5 of 689

Institutions

322

  1. University of Cambridge

    Cambridge, United Kingdom

    15 h-index

    57 publications

    14.4K citations

  2. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    11 h-index

    37 publications

    2.4K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    8 h-index

    24 publications

    4.8K citations

  4. University of Delaware

    Newark, United States

    7 h-index

    17 publications

    2K citations

  5. Bristol-Myers Squibb (United States)

    New York, United States

    6 h-index

    21 publications

    1.1K citations

  6. Forschungszentrum Jülich

    Jülich, Germany

    5 h-index

    19 publications

    603 citations

  7. University of California, Berkeley

    Berkeley, United States

    5 h-index

    14 publications

    550 citations

  8. Heinrich Heine University Düsseldorf

    Düsseldorf, Germany

    4 h-index

    8 publications

    233 citations

1–8 of 322

Venues

  1. The Journal of Physical Chemistry B

    15 publications · 1.1K citations

    14

    h-index

  2. Biophysical Journal

    11 publications · 612 citations

    11

    h-index

  3. The Journal of Chemical Physics

    10 publications · 307 citations

    10

    h-index

  4. Journal of Molecular Biology

    JMB · 8 publications · 1.4K citations

    8

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 1.3K citations

    7

    h-index

1–5