Concepedia

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

Christopher J. Phiel, Virginia M.‐Y. Lee, Peter S. Klein

Nature · 2003 · 1.2K citations · 28 references

DOI

Concepts

References

28

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.4K citations

, , +7

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

, , +17

A molecular mechanism for the effect of lithium on development.

Peter S. Klein, Douglas A. Melton · Proceedings of the National Academy of Sciences · 1996 · 2.3K citations

, , +11

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

, , +12

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

, , +8