Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Life Sciences, Developmental Biology, Molecular Biology +12

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

Erik N. Meyers, Mark Lewandoski, Gail R. Martin · Nature Genetics · 1998 · 1K citations

Medicine, Genetics, Molecular Genetics +12

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

Ramiro Ramfrez-Solis, Hui Zheng, Jenny Whiting et al. · Cell · 1993 · 348 citations

Life Sciences, Developmental Biology, Genetics +16

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

Steven Fiering, Elliot Epner, K. Robinson et al. · Genes & Development · 1995 · 346 citations · Full text

Life Sciences, Genetics, Molecular Genetics +8

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

Paul Hasty, Ramiro Ramírez‐Solis, Robb Krumlauf et al. · Nature · 1991 · 334 citations

Life Sciences, Developmental Biology, Genetics +16